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Peroxisome proliferator-activated receptor alpha （PPARα） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 （22q12-13.1）.

 

Species   Gene Symbol     Gene Accession No.     Protein Accession No.

Human     PPARA                 NM_001001928          Q07869

Mouse      Ppara                    NM_011144              P23204

Rat           Ppara                    NM_013196              P37230

 

抑制劑

 

 

 

GW 6471

 

分子量:635.68     分子式:C35H36F3N3O5

Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:>98 %                10mg ，50mg 規格

CAS No:[436159-64-7]         

Chemical Name:[（2S）-2-[[（1Z）-1-Methyl-3-oxo-3-[4-（trifluoromethyl）phenyl]-1-propenyl]amino]-3-[4-[2-（5-methyl-2-phenyl-4-oxazolyl）ethoxy]phenyl]propyl]-carbamic acid ethyl ester

 

Sold with the permission of GlaxoSmithKline   過氧化物酶增殖活化受體α抑制劑 GW6471    PPARα 系列產品

PPARα抑制劑 that inhibits activation with an IC50 value of 0.24μM.

 

MK 886

 

分子量:472.08       分子式:C27H34ClNO2S

Solubility:Soluble to 5 mM in ethanol and to 100 mM in DMSO

Purity:>98 %             10mg ，50mg 規格

Storage:Store at RT

CAS No:[118414-82-7]

Chemical Name: 1-[（4-Chlorophenyl）methyl]-3-[（1,1-dimethylethyl）thio]-α,α-dimethyl-5-（1-methylethyl）-1H-Indole-2-propanoic acid

別名：L-663,536

An inhibitor of leukotriene biosynthesis （IC50 = 3 nM in human polymorphonuclear leukocytes）. Acts by inhibiting 5-lipoxygenase-activating protein （FLAP） （IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling）. Also moderay potent PPARα抑制劑 （IC50 = 0.5-1μM）. Orally activein vivo.

 

激動劑

 

GW 7647

分子量:502.75              分子式：C29H46N2O3S

Solubility:Soluble to 25 mM in ethanol and to 100 mM in DMSO      

Purity:>99 %                 10mg ，50mg 規格

CAS No:[265129-71-3]

Chemical Name: 2-[[4-[2-[[（Cyclohexylamino）carbonyl]（4-cyclohexylbutyl）amino]ethyl]phenyl]thio]-2-methylpropanoic acid

Potent and highly selective PPARαagonist （EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγand PPARδreceptors respectively）. Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubulesin vitro. Has lipid-lowering effects following oral administrationin vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties

 

Fenofibrate

分子量：360.83         分子式：C20H21ClO4

Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:>99 %              50mg 規格

Storage:Store at RT

CAS No:[49562-28-9]

Chemical Name: 2-[4-（4-Chlorobenzoyl）phenoxy]-2-methylpropanoic acid isopropyl ester

PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.

 

296638 [49562-28-9] Fenofibrate 

294030   Fenofibrate Imp. F （EP）: （4-Chlorophenyl）[4-（1-methyl-ethoxy 

294029   Fenofibrate Imp. E （EP）: Ethyl 2-[4-（4-Chlorobenzoyl）-phenox 

294028   Fenofibrate Imp. D （EP）: Methyl 2-[4-（4-Chlorobenzoyl）-pheno 

294027   Fenofibrate Imp. C （EP）: （3RS）-3-[4-（4-Chlorobenzoyl）-phenox 

294026   Fenofibrate Imp. A （EP）: （4-Chlorophenyl）（4-hydroxyphenyl）me 

294025   Fenofibrate 

290762   Fenofibrate impurity G 

290761   Fenofibrate impurity B 

290760   Fenofibrate impurity A 

290759   Fenofibrate 

288620 [49562-28-9] Fenofibrate 

261137   Fenofibrate-d6 

261136 49562-28-9 Fenofibrate 

259465   Dihydro Fenofibrate-d6 

259464 61001-99-8 Dihydro Fenofibrate 

257408 856676-23-8 Choline Fenofibrate 

 

 

Oleylethanolamide

分子量:325.53           分子式：C20H39NO2

Purity:>99 %              10mg ，50mg 規格

Storage:Store at +4°C

CAS No:[111-58-0]

Chemical Name: （9Z）-N-（2-Hydroxyethyl）-9-octadecenamide

 

Palmitoylethanolamide

分子量：299.5           分子式：C18N37NO2

Solubility:Soluble to 20 mM in DMSO and to 25 mM in ethanol

Storage:Store at RT       10mg ，50mg 規格    

CAS No:[544-31-0]

別名: PEA            Chemical Name: N-（2-Hydroxyethyl）hexadecanamid

 

WY 14643

 

分子量：323.8           分子式：C14H14ClN3O2S

Solubility:Soluble to 100 mM in DMSO

Purity:>98 %             10mg ，50mg 規格    

Storage:Store at RT

CAS No:[50892-23-4]

 

Chemical Name: [[4-Chloro-6-[（2,3-dimethylphenyl）amino]-2-pyrimidinyl]thio]acetic acid

 

其它相關產品：

 

PPARγ

Peroxisome proliferator-activated receptor gamma （PPARγ） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 （3p25）.

 

PPARγ Products

激動劑

 

Ciglitazone

GW 1929 hydrochloride

LG 100754

M.Wt:396.56       Formula:C26H36O3

Solubility:Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:>99 %             10mg ，50mg 規格

CAS No:[180713-37-5]

Chemical Name: （2E,4E,6Z）-3-Methyl-7-（5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl）-2,4,6-octatrienoic acid

Novel RXR:PPARγagonist; sensitizes PPARγby enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARαheterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRαand RXR:BAR/FXR. Exhibits antidiabetic propertiesin vivo.

 

nTZDpa

Pioglitazone hydrochlorideNew product

15-deoxy-Δ-12,14-Prostaglandin J2

S26948New productPrices displayed reflect a 25% discount off list price

Troglitazone

 

Ant激動劑：

 

BADGE

    PPARγ 抑制劑

GW 9662 Selective PPARγ 抑制劑

分子量：276.68          

分子式：C13H19N2O3Cl

Solubility:Soluble to 25 mM in ethanol

Purity:>98 %              10mg ，50mg 規格

Storage:Store at RT

CAS No:[22978-25-2]

Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide

Selective PPARγ 抑制劑 （IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively）. Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range （1-2 μM）, therefore is more potent than BADGE . Anticancer, inhibits growth of human mammary tumor cell lines.

 

SR 202

    Selective PPARγ 抑制劑; antidiabetic and antiobesity agent

T 0070907

    Highly potent and selective PPARγ 抑制劑

Other

Genistein

 

 

Peroxisome proliferator-activated receptor delta （PPARδ）, also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression.

PPARδ displays a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARδ has been localized to chromosome 6 （6p21.2）.

 

PPARδ Products

激動劑

GW 0742

L-165,041

Ant激動劑

GSK 0660

    Selective PPARδ 抑制劑

GSK 3787

    Potent and selective PPARδ 抑制劑

Modulators

Retinoic acid

 

Antibodies and Blocking Peptides

Anti-PPARδ